2-Methyl-5-p-tolyl-thiazole-4-carboxylic acid → (r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[1-(2-methyl-5-p-tolyl-thiazole-4-carbonyl)-piperidin-3-yl]-amide

HRID 1094269Notes

Reaction equation

HRID 1094269 reaction equation
[CH3:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)=[C:5]([C:7]([OH:9])=O)[N:6]=1.[NH:17]1[CH2:22][CH2:21][CH2:20][C@@H:19]([NH:23][C:24]([C:26]2[N:33]3[C:29]([S:30][CH:31]=[CH:32]3)=[N:28][C:27]=2[CH3:34])=[O:25])[CH2:18]1>>[CH3:1][C:2]1[S:3][C:4]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)=[C:5]([C:7]([N:17]2[CH2:22][CH2:21][CH2:20][C@@H:19]([NH:23][C:24]([C:26]3[N:33]4[C:29]([S:30][CH:31]=[CH:32]4)=[N:28][C:27]=3[CH3:34])=[O:25])[CH2:18]2)=[O:9])[N:6]=1

Participants

3

Reactant 2

HCID 532718172-Methyl-5-p-tolyl-thiazole-4-carboxylic acidHCID 66639497(r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid piperidin-3-ylamide

Product 1

HCID 24963405(r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid[1-(2-methyl-5-p-tolyl-thiazole-4-carbonyl)-piperidin-3-yl]-amide

Procedure

prepared by reaction of 2-methyl-5-p-tolyl-thiazole-4-carboxylic acid with (R)-6-methyl-imidazo[2,1-b]-thiazole-5-carboxylic acid-piperidin-3-ylamide.

Sources & evidence

ORD record
ord-424a86dce696455b93edc6052e52300c
Source dataset
uspto-grants-2012_03
Patent number
US08133901B2

Reaction notes

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