2-Methyl-5-(3,4-dimethyl-phenyl)-thiazole-4-carboxylic acid → (r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid{1-[5-(3,4-dimethyl-phenyl)-2-methyl-thiazole-4-carbonyl]-piperidin-3-yl}-amide

HRID 1094276Notes

Reaction equation

HRID 1094276 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[S:13][C:12]([CH3:14])=[N:11][C:10]=2[C:15]([OH:17])=O)[CH:5]=[CH:6][C:7]=1[CH3:8].[NH:18]1[CH2:23][CH2:22][CH2:21][C@@H:20]([NH:24][C:25]([C:27]2[N:34]3[C:30]([S:31][CH:32]=[CH:33]3)=[N:29][C:28]=2[CH3:35])=[O:26])[CH2:19]1>>[CH3:1][C:2]1[CH:3]=[C:4]([C:9]2[S:13][C:12]([CH3:14])=[N:11][C:10]=2[C:15]([N:18]2[CH2:23][CH2:22][CH2:21][C@@H:20]([NH:24][C:25]([C:27]3[N:34]4[C:30]([S:31][CH:32]=[CH:33]4)=[N:29][C:28]=3[CH3:35])=[O:26])[CH2:19]2)=[O:17])[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 574371772-Methyl-5-(3,4-dimethyl-phenyl)-thiazole-4-carboxylic acidHCID 66639497(r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid piperidin-3-ylamide

Product 1

HCID 24964108(r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid{1-[5-(3,4-dimethyl-phenyl)-2-methyl-thiazole-4-carbonyl]-piperidin-3-yl}-amide

Procedure

prepared by reaction of 5-(3,4-dimethyl-phenyl)-2-methyl-thiazole-4-carboxylic acid with (R)-6-methyl-imidazo[2,1-b]-thiazole-5-carboxylic acid-piperidin-3-ylamide.

Sources & evidence

ORD record
ord-4da212f6285b43b085168c739cf0057f
Source dataset
uspto-grants-2012_03
Patent number
US08133901B2

Reaction notes

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