(r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid piperidin-3-ylamide → (r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid{1-[5-(3,4-difluoro-phenyl)-2-methyl-thiazole-4-carbonyl]-piperidin-3-yl}-amide

HRID 1094278Notes

Reaction equation

HRID 1094278 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[S:13][C:12]([CH3:14])=[N:11][C:10]=2[C:15]([OH:17])=O)[CH:5]=[CH:6][C:7]=1[F:8].[NH:18]1[CH2:23][CH2:22][CH2:21][C@@H:20]([NH:24][C:25]([C:27]2[N:34]3[C:30]([S:31][CH:32]=[CH:33]3)=[N:29][C:28]=2[CH3:35])=[O:26])[CH2:19]1>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[S:13][C:12]([CH3:14])=[N:11][C:10]=2[C:15]([N:18]2[CH2:23][CH2:22][CH2:21][C@@H:20]([NH:24][C:25]([C:27]3[N:34]4[C:30]([S:31][CH:32]=[CH:33]4)=[N:29][C:28]=3[CH3:35])=[O:26])[CH2:19]2)=[O:17])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 66639497(r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid piperidin-3-ylamideHCID 666395805-(3,4-Difluorophenyl)-2-methylthiazole-4-carboxylic acid

Product 1

HCID 24964110(r)-6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid{1-[5-(3,4-difluoro-phenyl)-2-methyl-thiazole-4-carbonyl]-piperidin-3-yl}-amide

Procedure

prepared by reaction of 5-(3,4-difluoro-phenyl)-2-methyl-thiazole-4-carboxylic acid with (R)-6-methyl-imidazo[2,1-b]-thiazole-5-carboxylic acid-piperidin-3-ylamide.

Sources & evidence

ORD record
ord-84da98337a444a5ea08a7fe24222b499
Source dataset
uspto-grants-2012_03
Patent number
US08133901B2

Reaction notes

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