2-Methyl-5-(3,4-dimethyl-phenyl)-thiazole-4-carboxylic acid → HCID 24964471, compound

HRID 1094279Notes

Reaction equation

HRID 1094279 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5]([NH:8][C@@H:9]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10]2)=[N:6][CH:7]=1.[CH3:15][C:16]1[CH:17]=[C:18]([C:23]2[S:27][C:26]([CH3:28])=[N:25][C:24]=2[C:29](O)=[O:30])[CH:19]=[CH:20][C:21]=1[CH3:22]>>[Br:1][C:2]1[CH:3]=[N:4][C:5]([NH:8][C@@H:9]2[CH2:14][CH2:13][CH2:12][N:11]([C:29]([C:24]3[N:25]=[C:26]([CH3:28])[S:27][C:23]=3[C:18]3[CH:19]=[CH:20][C:21]([CH3:22])=[C:16]([CH3:15])[CH:17]=3)=[O:30])[CH2:10]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 574371772-Methyl-5-(3,4-dimethyl-phenyl)-thiazole-4-carboxylic acidHCID 66639492HCID 66639492, compound

Product 1

HCID 24964471HCID 24964471, compound

Procedure

prepared by reaction of (R)-(5-bromo-pyrimidin-2-yl)-piperidin-3-yl-amine with 5-(3,4-dimethyl-phenyl)-2-methyl-thiazole-4-carboxylic acid.

Sources & evidence

ORD record
ord-701f8b6b9f634aa0a75b31f252907816
Source dataset
uspto-grants-2012_03
Patent number
US08133901B2

Reaction notes

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