Isophthalic Acid → HCID 11996753, compound

HRID 1094286Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([O:10][C:11](=[O:25])[NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:6][CH2:5]1.[C:26]([OH:37])(=O)[C:27]1[CH:35]=[CH:34][CH:33]=[C:29]([C:30]([OH:32])=O)[CH:28]=1>>[NH2:1][CH2:2][CH2:3][NH:4][C:30]([C:29]1[CH:28]=[C:27]([CH:35]=[CH:34][CH:33]=1)[C:26]([NH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([O:10][C:11](=[O:25])[NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH2:6][CH2:5]1)=[O:37])=[O:32]

Participants

Reactant 2

HCID 8496Isophthalic Acid

HCID 53319786Biphenyl-2-ylcarbamic acid 1-(2-aminoethyl)piperidin-4-yl ester

Product 1

HCID 11996753HCID 11996753, compound

Procedure

The title compound was prepared following a similar procedure as described in Example 13, by substituting the appropriate biphenyl-2-ylcarbamic acid 1-(aminoethyl)piperidin-4-yl ester in place of biphenyl-2-ylcarbamic acid 1-(2-methylaminoethyl)piperidin-4-yl ester and substituting isophthalic acid in place of terephthalic acid.

Sources & evidence

ORD record: ord-a80452d2cfad4b39bf5e141392c7080f
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08133905B2

Reaction notes

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