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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1094312Generated: November 2, 2026

5-(2-Methylpropyl)thiophene-2-carboxylic acid → 2-Ethyl-4-[5-(5-isobutyl-thiophen-2-yl)-[1,3,4]oxadiazol-2-yl]-6-methyl-phenol

https://huagongshe.com/reaction/1094312

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(2-Methylpropyl)thiophene-2-carboxylic acidHCID 19622689—
Reactant4-Benzyloxy-3-ethyl-5-methyl-benzoic acid hydrazideHCID 59202026—
Product2-Ethyl-4-[5-(5-isobutyl-thiophen-2-yl)-[1,3,4]oxadiazol-2-yl]-6-methyl-phenolHCID 136029938—

Reaction Steps

2-Ethyl-4-[5-(5-isobutyl-thiophen-2-yl)-[1,3,4]oxadiazol-2-yl]-6-methyl-phenol is prepared in analogy to Example 29 from 5-isobutyl-thiophene-2-carboxylic acid and 4-benzyloxy-3-ethyl-5-methyl-benzoic acid hydrazide; LC-MS: tR=1.03 min, [M+1]+=343.22.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08133910B2
Source datasetuspto-grants-2012_03
ORD IDord-fb3a35b5aa024e2188f21d0b68f4c2a7
Source noteuspto-grants-2012_03