HCID 86645979, compound → HCID 86645980, compound

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Reaction Steps

A solution of methyl (4R)-3-oxo-4-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)pentanoate (372 mg, 1 mmol) in AcOH (10 ml) and 37% HCl (1.5 ml) was refluxed for 12 h. After cooling at room temperature and solvents evaporation, the crude product was diluted with CH2Cl2 (10 ml), washed with water (3×5 ml) and brine (3×5 ml) and dried over anhydrous Na2SO4. After solvent evaporation the resulting pale yellow oil was pulped overnight in n-hexane. Pure (4R)-3-oxo-4-(4-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}phenyl)pentanoic acid (283 mg, 0.79 mmol) was isolated as a white solid by filtration (79%).

Provenance & Evidence