Phenylglyoxylic Acid → 2-Oxo-2-phenyl-N-(5,6,7,8-tetrahydro-naphthalen-2-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide

Participants

Reaction Steps

In analogy to example 7, step 1, (5,6,7,8-tetrahydro-naphthalen-2-yl)-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-amine (250 mg, 0.78 mmol, prepared as described in example 9, step 1) and benzoylformic acid (141 mg, 0.939 mmol) were coupled to provide the title compound (355 mg, 100%) as a yellow oil which was used without further purification in the next step.

Provenance & Evidence