1-(2-Bromoethyl)-4-(trifluoromethyl)benzene → HCID 58007527, compound

HRID 1094386Notes

Reaction equation

HRID 1094386 reaction equation
[CH3:1][C:2]1[N:7]=[CH:6][C:5]([NH:8][C:9](=[O:18])[C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.Br[CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=1>>[CH3:1][C:2]1[N:7]=[CH:6][C:5]([N:8]([CH2:20][CH2:21][C:22]2[CH:23]=[CH:24][C:25]([C:28]([F:29])([F:30])[F:31])=[CH:26][CH:27]=2)[C:9](=[O:18])[C:10](=[O:17])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 149499411-(2-Bromoethyl)-4-(trifluoromethyl)benzeneHCID 58007594N-(6-methyl-pyridin-3-yl)-2-oxo-2-phenyl-acetamide

Product 1

HCID 58007527HCID 58007527, compound

Procedure

In analogy to the procedure described for the synthesis example 43 (step 2), the title compound N-(6-methyl-pyridin-3-yl)-2-oxo-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide (MS m/e: 413.2 [M+H]+) was prepared from N-(6-methyl-pyridin-3-yl)-2-oxo-2-phenyl-acetamide and 1-(2-bromo-ethyl)-4-trifluoromethyl-benzene.

Workup

  1. customIn analogy to the procedure described for the synthesis example 43 (step 2)

Sources & evidence

ORD record
ord-8189dbf875354cdeaeba73cbf73e1ba7
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

Loading…