1-(2-Bromoethyl)-4-(trifluoromethyl)benzene → HCID 58007611, compound

HRID 1094390Notes

Reaction equation

HRID 1094390 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9](=[O:18])[C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:5]=[CH:4][N:3]=1.Br[CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([N:8]([CH2:20][CH2:21][C:22]2[CH:23]=[CH:24][C:25]([C:28]([F:29])([F:30])[F:31])=[CH:26][CH:27]=2)[C:9](=[O:18])[C:10](=[O:17])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 149499411-(2-Bromoethyl)-4-(trifluoromethyl)benzeneHCID 58007539HCID 58007539, compound

Product 1

HCID 58007611HCID 58007611, compound

Procedure

In analogy to the procedure described for the synthesis example 43 (step 2), the title compound N-(2-methyl-pyridin-4-yl)-2-oxo-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide (MS m/e: 413.2 [M+H]+) was prepared from N-(2-methyl-pyridin-4-yl)-2-oxo-2-phenyl-acetamide and 1-(2-bromo-ethyl)-4-trifluoromethyl-benzene.

Workup

  1. customIn analogy to the procedure described for the synthesis example 43 (step 2)

Sources & evidence

ORD record
ord-606d7b4215624a4184336dfee508ee45
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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