HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1094396Generated: October 31, 2026
Ammonium formate → (1-Ethyl-3-methyl-1H-indazol-5-yl)-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-amine
https://huagongshe.com/reaction/1094396
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| Reactant | 1-Ethyl-3-methyl-5-nitro-1H-indazole | HCID 58007574 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (1-Ethyl-3-methyl-1H-indazol-5-yl)-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-amine | HCID 58007588 | 61% |
Reaction Steps
A solution of (6-trifluoromethyl-pyridin-3-yl)-acetonitrile (849 mg, 4.14 mmol, prepared as per example 47, step 1) and 1-ethyl-3-methyl-5-nitro-1H-indazole (700 mg, 3.76 mmol) in MeOH (10 mL) was treated with ammonium formate (5 eq.) and 10% Pd/C (140 mg) and stirred at 80° C. for 2 h. Filtration, concentration and purification by chromatography (SiO2, heptane:ethyl acetate=95:5 to 60:40) afforded the title compound (794 mg, 61%) as a light yellow oil. MS m/e: 349.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08133909B2 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-43bfc9b5d33a4a568f633cdf9e6ccf9d |
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| Source note | uspto-grants-2012_03 |
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