HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-1,3-benzoxazol-5-amine → (s)-2-Hydroxy-n-(2-methyl-benzooxazol-5-yl)-2-phenyl-n-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-1,3-benzoxazol-5-amine | HCID 737920 | — |
| Reactant | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| Reactant | acetyl (2S)-2-hydroxy-2-phenylacetate | HCID 87431886 | — |
| Product | (s)-2-Hydroxy-n-(2-methyl-benzooxazol-5-yl)-2-phenyl-n-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide | HCID 58007543 | — |
Reaction Steps
In analogy to example 49, 2-Methyl-benzooxazol-5-ylamine, (6-Trifluoromethyl-pyridin-3-yl)-acetonitrile & (S)-(+)-O-acetyl-L-mandelic acid were successively coupled and hydrolysed to give the target compound. MS(m/e): 456.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08133909B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-4efca591951b472c809a6d53189ec8ae |
| Source note | uspto-grants-2012_03 |