HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1094404Generated: October 30, 2026
1,4-Benzodioxan-6-ylamine → HCID 58007533, compound
https://huagongshe.com/reaction/1094404
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Benzodioxan-6-ylamine | HCID 89148 | — |
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 58007533 | HCID 58007533 | 24% |
Reaction Steps
A solution of 5 mmol (6-trifluoromethyl-pyridin-3-yl)-acetonitrile (prepared as per example 47, step 1) and 1.1 eq. 2,3-Dihydro-benzo[1,4]dioxin-6-ylamine in MeOH (20 mL) was treated with ammonium formate (5 eq.) and 10% Pd/C (200 mg) and stirred at 80° C. for 2 h. Filtration, concentration and purification by chromatography (SiO2, heptane:ethyl acetate=95:5 to 60:40) afforded the title compound (24%) as a light yellow oil. MS m/e: 325.0 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08133909B2 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-8fc4cc918d9e411f8838038da0b0fe0a |
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| Source note | uspto-grants-2012_03 |
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