HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dimethylaniline → (s)-n-[2-(5-Chloro-pyridin-2-yl)-ethyl]-n-(3,4-dimethyl-phenyl)-2-hydroxy-2-phenyl-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dimethylaniline | HCID 7248 | — |
| Reactant | 5-Chloro-2-ethenylpyridine | HCID 15547626 | — |
| Reactant | acetyl (2S)-2-hydroxy-2-phenylacetate | HCID 87431886 | — |
| Product | (s)-n-[2-(5-Chloro-pyridin-2-yl)-ethyl]-n-(3,4-dimethyl-phenyl)-2-hydroxy-2-phenyl-acetamide | HCID 44546442 | — |
Reaction Steps
In analogy to example 25 step 1 and 26 step 1-2, [2-(5-Chloro-pyridin-2-yl)-ethyl]-(3,4-dimethyl-phenyl)-amine obtained by reacting 5-Chloro-2-vinyl-pyridine (CAS: 223445-06-5) with 3,4-dimethylaniline was coupled with (S)-(+)-O-acetyl-L-mandelic acid then hydrolysed to provide the title compound. MS(m/e): 395.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08133909B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-11cda96bc6324d039e9dfc47a97d2dd9 |
| Source note | uspto-grants-2012_03 |