HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Iodo-1,2-dimethylbenzene → (s)-n-(3,4-Dimethyl-phenyl)-2-hydroxy-2-phenyl-n-(2-thiophen-3-yl-ethyl)-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Iodo-1,2-dimethylbenzene | HCID 141646 | — |
| Reactant | 2-(3-Thienyl)ethanamine | HCID 12258737 | — |
| Reactant | acetyl (2S)-2-hydroxy-2-phenylacetate | HCID 87431886 | — |
| Product | (s)-n-(3,4-Dimethyl-phenyl)-2-hydroxy-2-phenyl-n-(2-thiophen-3-yl-ethyl)-acetamide | HCID 58007551 | — |
Reaction Steps
In analogy to example 22 step 1 and 26 step 1-2, (3,4-dimethyl-phenyl)-(2-thiophen-3-yl-ethyl)-amine obtained by reacting 2-thiophen-3-yl-ethylamine (commercial) with 4-iodo-o-xylene (commercial) was coupled with (S)-(+)-O-acetyl-L-mandelic acid then hydrolysed to provide the title compound. MS(m/e): 366.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08133909B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-56b8f36f1dd14125877732f11e1648b8 |
| Source note | uspto-grants-2012_03 |