4-Bromo-2-fluorotoluene → HCID 58007487, compound

HRID 1094422Notes

Reaction equation

HRID 1094422 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[C:4]([F:9])[CH:3]=1.[F:10][C:11]([F:22])([F:21])[C:12]1[CH:13]=[CH:14][C:15]([CH2:18][CH2:19][NH2:20])=[N:16][CH:17]=1>>[F:9][C:4]1[CH:3]=[C:2]([NH:20][CH2:19][CH2:18][C:15]2[CH:14]=[CH:13][C:12]([C:11]([F:22])([F:10])[F:21])=[CH:17][N:16]=2)[CH:7]=[CH:6][C:5]=1[CH3:8]

Participants

3

Reactant 2

HCID 1710404-Bromo-2-fluorotolueneHCID 180713442-(5-Trifluoromethyl-pyridin-2-YL)-ethylamine

Product 1

HCID 58007487HCID 58007487, compound

Procedure

In analogy to the procedure described for the synthesis example 71 (step 1), the title compound (3-fluoro-4-methyl-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 299.3 [M+H]+) was prepared from 4-bromo-2-fluorotoluene instead of 6-bromo-2,3-dihydro-benzofuran and 2-(5-trifluoromethyl-pyridin-2-yl)-ethylamine instead of 2-(6-trifluoromethyl-pyridin-3-yl)-ethylamine.

Workup

  1. customIn analogy to the procedure described for the synthesis example 71 (step 1)

Sources & evidence

ORD record
ord-5a694b30df584a988a7ba1676f4e0d25
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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