HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(5-Trifluoromethyl-pyridin-2-YL)-ethylamine → 1-methyl-6-[2-(5-trifluoromethyl-pyridin-2-yl)-ethylamino]-3,4-dihydro-1H-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(5-Trifluoromethyl-pyridin-2-YL)-ethylamine | HCID 18071344 | — |
| Reactant | 6-Bromo-1-methyl-1,2,3,4-tetrahydroquinolin-2-one | HCID 63106141 | — |
| Product | 1-methyl-6-[2-(5-trifluoromethyl-pyridin-2-yl)-ethylamino]-3,4-dihydro-1H-quinolin-2-one | HCID 58007595 | — |
Reaction Steps
In analogy to the procedure described for the synthesis example 71 (step 1), the title compound 1-methyl-6-[2-(5-trifluoromethyl-pyridin-2-yl)-ethylamino]-3,4-dihydro-1H-quinolin-2-one (MS m/e: 350.3 [M+H]+) was prepared from 6-bromo-1-methyl-3,4-dihydro-1H-quinolin-2-one instead of 6-bromo-2,3-dihydro-benzofuran and 2-(5-trifluoromethyl-pyridin-2-yl)-ethylamine instead of 2-(6-trifluoromethyl-pyridin-3-yl)-ethylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08133909B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-ac89e51c605f4bb7b124a3d2474cf60d |
| Source note | uspto-grants-2012_03 |