1-Bromo-4-iodobenzene → HCID 58007612, compound

HRID 1094430Notes

Reaction equation

HRID 1094430 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5](I)=[CH:4][CH:3]=1.[F:9][C:10]([F:21])([F:20])[C:11]1[CH:12]=[CH:13][C:14]([CH2:17][CH2:18][NH2:19])=[N:15][CH:16]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:19][CH2:18][CH2:17][C:14]2[CH:13]=[CH:12][C:11]([C:10]([F:21])([F:9])[F:20])=[CH:16][N:15]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 115221-Bromo-4-iodobenzeneHCID 180713442-(5-Trifluoromethyl-pyridin-2-YL)-ethylamine

Product 1

HCID 58007612HCID 58007612, compound

Procedure

In analogy to the procedure described for the synthesis example 71 (step 1), the title compound (4-bromo-phenyl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 347.0 [M+H]+) was prepared from 1-bromo-4-iodo-benzene instead of 6-bromo-2,3-dihydro-benzofuran and 2-(5-trifluoromethyl-pyridin-2-yl)-ethylamine instead of 2-(6-trifluoromethyl-pyridin-3-yl)-ethylamine.

Workup

  1. customIn analogy to the procedure described for the synthesis example 71 (step 1)

Sources & evidence

ORD record
ord-3c0ca02ea9524d53befacc953b5f293c
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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