5-Amino-1,3-dihydro-2lambda6-benzothiophene-2,2-dione → HCID 58007524, compound

HRID 1094432Notes

Reaction equation

HRID 1094432 reaction equation
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]2[CH2:6][S:7](=[O:10])(=[O:9])[CH2:8][C:4]=2[CH:3]=1.[F:13][C:14]([F:24])([F:23])[C:15]1[CH:16]=[CH:17][C:18]([CH:21]=[CH2:22])=[N:19][CH:20]=1>>[O:9]=[S:7]1(=[O:10])[CH2:8][C:4]2[CH:3]=[C:2]([NH:1][CH2:22][CH2:21][C:18]3[CH:17]=[CH:16][C:15]([C:14]([F:24])([F:13])[F:23])=[CH:20][N:19]=3)[CH:12]=[CH:11][C:5]=2[CH2:6]1

Participants

3

Reactant 2

HCID 28219175-Amino-1,3-dihydro-2lambda6-benzothiophene-2,2-dioneHCID 58933992HCID 58933992, compound

Product 1

HCID 58007524HCID 58007524, compound

Procedure

In analogy to the procedure described for the synthesis example 25 (step 1), the title compound (2,2-dioxo-2,3-dihydro-1H-2lambda(6)-benzo[c]thiophen-5-yl)-[2-(5-trifluoromethyl-pyridin-2-yl)-ethyl]-amine (MS m/e: 357.1 [M+H]+) was prepared from 5-amino-2,3-dihydro-1H-2lambda(6)-benzo[c]thiophene-2,2-dione instead of 3,4-dimethylaniline and 5-trifluoromethyl-2-vinyl-pyridine.

Workup

  1. customIn analogy to the procedure described for the synthesis example 25 (step 1)

Sources & evidence

ORD record
ord-ecb544c6db6c48aea5bff54f0393fb42
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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