HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1094439Generated: October 29, 2026
4-(Trifluoromethyl)phenylacetonitrile → HCID 58007561, compound
https://huagongshe.com/reaction/1094439
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(Trifluoromethyl)phenylacetonitrile | HCID 75359 | — |
| Reactant | Ammonium formate | HCID 2723923 | — |
| Reactant | Aminoquinol | HCID 5708341 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 58007561 | HCID 58007561 | 73% |
Reaction Steps
A solution of 10.4 mmol 4-(trifluoromethyl)phenylacetonitrile (commercially available) and 3.5 eq. aminoquinoline in MeOH (10 mL) was treated with ammonium formate (5 eq.) and 10% Pd/C (100 mg) and stirred at 80° C. for 2 h. Filtration, concentration and purification by chromatography (SiO2, CH2Cl2/MeOH) afforded the title compound (73%) as a yellow oil. MS m/e: 317.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08133909B2 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-96af17530c27410d82d9e47b838b06ca |
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| Source note | uspto-grants-2012_03 |
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