HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Fluorophenyl)-2-oxoacetic Acid → (S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(3-methyl-1H-indazol-5-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Fluorophenyl)-2-oxoacetic Acid | HCID 579440 | — |
| Reactant | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| Reactant | HCID 178434299 | HCID 178434299 | — |
| Product | (S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(3-methyl-1H-indazol-5-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide | HCID 178434301 | — |
Reaction Steps
In analogy to example 47, 3-Methyl-1H-indazol-5-ylamine, (6-Trifluoromethyl-pyridin-3-yl)-acetonitrile & (4-fluoro-phenyl)-oxo-acetic acid were successively coupled then reduced to give after silica gel and chiral chromatography the target compound. MS(m/e): 473.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08133909B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-5771199981f34e7a965c33497b8433a4 |
| Source note | uspto-grants-2012_03 |