HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1094449Generated: October 29, 2026
Boron tribromide → 2-(Bromomethyl)-1-fluoro-4-methylbenzene
https://huagongshe.com/reaction/1094449
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | (2-Fluoro-5-methylphenyl)methanol | HCID 12407611 | — |
| Product | 2-(Bromomethyl)-1-fluoro-4-methylbenzene | HCID 17750800 | — |
Reaction Steps
An oven dried round bottom flask is charged with boron tribromide (13 mL, 140 mmol) and is cooled to −30-45° C. 2-Fluoro-5-methyl-benzyl alcohol (6.5 g, 46 mmol) is then added slowly after which time the reaction is allowed to warm to room temperature.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08133907B2 |
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| Source dataset | uspto-grants-2012_03 |
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| ORD ID | ord-7bf477cd05cf4987864ad1328f7ce14c |
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| Source note | uspto-grants-2012_03 |
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