Hydrochloric Acid → HCID 66639173, compound

Participants

Reaction Steps

To a solution of 2-tert-butoxycarbonylamino-3-(2-fluoro-5-methylphenyl)-propionic acid ethyl ester (7.7 g, 24 mmol) in 60 mL of THF and 60 mL of MeOH is added lithium hydroxide (1.5 g, 35.6 mmol) in H2O (15 mL). The reaction is stirred at room temperature for 1.5 hr after which time 1M HCl is added until the mixture reaches pH 4. The product is extracted into dichloromethane and the combine the organic layers are dried over MgSO4, filtered, and concentrated to give the title compound.

Provenance & Evidence