Water → HCID 66638711, compound

Participants

Reaction Steps

To a solution of 2-[3-tert-butoxycarbonylamino-4-(2-fluoro-phenyl)-2-oxo-butyl]-nicotinic acid (14 g, 35 mmol) in 100 mL of EtOH at 0° C. is added NaBH4 (5.3 g, 140 mmol). After 20 min, 30 mL of water is added to the reaction and the reaction poured into 300 ml of water. The pH is adjusted to ˜pH3 with 2M NaHSO4 at which point a white solid precipitates and isolation by filtration gives the title compound.

Provenance & Evidence