Lithium Hydroxide → HCID 59799842, compound

Participants

Reaction Steps

To a solution of 2-[(4R,5S)-3-tert-butoxycarbonyl-4-(2-fluoro-benzyl)-2,2-dimethyl-oxazolidin-5-ylmethyl]-nicotinic acid methyl ester (5.5 g, 12 mmol) in 100 mL of dioxane/water (2:1) is added lithium hydroxide (0.57 g, 24 mmol). The reaction is stirred at room temperature for 2 hr after which time the reaction is diluted and the pH adjusted to pH 4-5 with a 2M solution of sodium bisulfate. The product is extracted into dichloromethane and the combined organic phases are dried over sodium sulfate, filtered, and concentrated under reduced pressure. Purification of the resultant residue by silica gel flash column chromatography gives the title compound.

Provenance & Evidence