Aluminium lithium hydride → HCID 66639453, compound

Participants

Reaction Steps

To a solution of (R)-2-Dibenzylamino-3-(2-fluoro-phenyl)-propionic acid methyl ester (4.6 g, 12 mmol) in 100 mL of THF at −10° C. is slowly added a 1M solution of lithium aluminum hydride in THF (19 mL, 18 mmol). After 10 minutes the reaction is quenched by slow addition of 1.2 mL of water and 1.2 mL of 1N sodium hydroxide. The mixture is then filtered through a pad of celite and the filtrate is concentrated to give the title compound.

Provenance & Evidence