HCID 66639453, compound → HCID 59799850, compound

Participants

Reaction Steps

To a solution of (R)-2-dibenzylamino-3-(2-fluoro-phenyl)-propan-1-ol (1 g, 2.9 mmol) in 2 mL of diisopropyl-ethyl-amine at 10° C. is slowly added a solution of sulfur trioxide pyridine complex (1.4 g, 8.6 mmol) in 5 mL of DMSO. The reaction is allowed to stir at room temperature for 45 minutes after which time the reaction is quenched by addition of ice water. The product is extracted into ether and the combined organic phases are washed with water, 5% citric acid, and brine. The organic layer is dried over sodium sulfate, filtered, and concentrated under reduce pressure to give the title compound.

Provenance & Evidence