Potassium tert-butoxide → HCID 66638929, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of (3-ethoxycarbonyl-pyridin-2-ylmethyl)-trimethyl-phosphonium bromide (0.9 g, 2.6 mmol) in 50 mL of ether is added potassium tert-butoxide (0.32 g, 2.9 mmol) and the reaction is heated at reflux for 30 minutes. The reaction is then cooled to −78° C., a solution of (R)-2-dibenzylamino-3-(2-fluoro-phenyl)-propionaldehyde (1.8 g, 3.5 mmol) in 10 mL of ether is added, and the reaction is allowed to stir at room temperature for 16 hours. The reaction is then concentrated under reduced pressure and purification of the resultant residue by silica gel flash column chromatography gives the title compound.

Provenance & Evidence