N-tert-Butyl-2-methylpyridine-3-carboxamide → HCID 66639008, compound

HRID 1094467Notes

Reaction equation

HRID 1094467 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][C@@H:8]([C:17](=[O:22])N(OC)C)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16])([CH3:4])([CH3:3])[CH3:2].[C:24]([NH:28][C:29](=[O:37])[C:30]1[CH:35]=[CH:34][CH:33]=[N:32][C:31]=1[CH3:36])(C)([CH3:26])[CH3:25]>>[C:1]([O:5][C:6](=[O:23])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[F:16])[C:17](=[O:22])[CH2:36][C:31]1[C:30]([C:29](=[O:37])[NH:28][CH:24]([CH3:25])[CH3:26])=[CH:35][CH:34]=[CH:33][N:32]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 59799806N-tert-Butyl-2-methylpyridine-3-carboxamideHCID 59799859[(R)-2-(2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester

Product 1

HCID 66639008HCID 66639008, compound

Procedure

Using general procedure 2 with [(R)-2-(2-fluoro-phenyl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester (0.65 g, 2.0 mmol) and substituting N-isopropyl-2-methyl-nicotinamide for N-tert-butyl-2-methyl-nicotinamide gives the title compound.

Sources & evidence

ORD record
ord-1bf583ca7e4542958d05b2b239a7fefa
Source dataset
uspto-grants-2012_03
Patent number
US08133907B2

Reaction notes

Loading…