Cyclopropylamine → HCID 66639631, compound

HRID 1094471Notes

Reaction equation

[C:1]([O:5][C:6]([N:8]1[C@H:12]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])[C@H:11]([CH2:21][C:22]2[N:30]=[CH:29][CH:28]=[CH:27][C:23]=2[C:24](O)=[O:25])[O:10][C:9]1([CH3:32])[CH3:31])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH:33]1([NH2:36])[CH2:35][CH2:34]1>>[C:1]([O:5][C:6]([N:8]1[C@H:12]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[F:20])[C@H:11]([CH2:21][C:22]2[C:23]([C:24](=[O:25])[NH:36][CH:33]3[CH2:35][CH2:34]3)=[CH:27][CH:28]=[CH:29][N:30]=2)[O:10][C:9]1([CH3:32])[CH3:31])=[O:7])([CH3:3])([CH3:4])[CH3:2]

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 59799842HCID 59799842, compound

Product 1

HCID 66639631HCID 66639631, compound

Procedure

Using general reaction procedure 5 with 2-[(4R,5S)-3-tert-butoxycarbonyl-4-(2-fluoro-benzyl)-2,2-dimethyl-oxazolidin-5-ylmethyl]-nicotinic acid (0.3 g, 0.67 mmol) and cyclopropylamine (0.23 mL, 3.4 mmol) gives the title compound.

Sources & evidence

ORD record: ord-664aeec88e0948d0a7fa8b34cf2063b6
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08133907B2

Reaction notes

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