Triethylamine → HCID 86622980, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-2-Dibenzylamino-3-(2,5-difluoro-phenyl)-propan-1-ol (5.10 g, 13.9 mmol) in DMSO (1 mL) and Triethylamine (7.83 mL, 56.2 mmol) at −9° C. is added a solution of Sulfur Trioxide Pyridine Complex (4.43 g, 27.3 mmol) in DMSO (19.6 mL) over a period of 60 min, the reaction temperature is maintained below 4° C. The reaction is allowed to stir an additional 15 min at 0-3° C. after which the reaction is quenched by addition of water (50 mL) over a period of 60 min, the reaction temperature is maintained below 10° C. The product is extracted into MTBE, the organic phase is dried over sodium sulfate, filtered, and concentrated under reduced pressure to provide the title compound.

Provenance & Evidence