Methylamine → HCID 23652717, compound

Participants

Reaction Steps

A solution of 50 mg (0.106 mMol) 6-(2-chloropyrimidin-4-yloxy)-benzooxazole-3-carboxylic acid (4-chloro-3-trifluoromethyl-phenyl)-amide in 1.5 ml THF and 107 μl MeNH2 (2 M in THF; 0.214 mMol) is stirred in a sealed vessel for 24 h at rt. Concentration of the reaction mixture and chromatography (Combi Flash; hexane/EtOAc 4:1-1:1) gives the title compound: MS: [M+1]+=466; HPLC: tRet=13.8; TLC(hexane/EtOAc 1:1): Rf=0.09.

Provenance & Evidence