3-(Trifluoromethyl)aniline → HCID 178522042, compound

HRID 1094493Notes

Reaction equation

HRID 1094493 reaction equation
[OH:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([CH2:8][C:9]2[CH:10]=[C:11]3[C:16](=[CH:17][CH:18]=2)[C:15]([C:19]([OH:21])=O)=[CH:14][CH:13]=[CH:12]3)[CH:3]=1.[F:22][C:23]([F:32])([F:31])[C:24]1[CH:25]=[C:26]([CH:28]=[CH:29][CH:30]=1)[NH2:27]>C(Cl)Cl.CO>[F:22][C:23]([F:31])([F:32])[C:24]1[CH:25]=[C:26]([NH:27][C:19]([C:15]2[C:16]3[C:11](=[CH:10][C:9]([CH2:8][C:4]4[CH:3]=[C:2]([OH:1])[N:7]=[CH:6][N:5]=4)=[CH:18][CH:17]=3)[CH:12]=[CH:13][CH:14]=2)=[O:21])[CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 178524206HCID 178524206, compound

Product 1

HCID 178522042HCID 178522042, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared from 6-(6-hydroxy-pyrimidin-4-ylmethyl)-naphthalene-1-carboxylic acid (Step 3.8) and 3-trifluoromethyl-aniline analogously to Ex. 3: MS: [M+1]+=424; TLC (CH2Cl2/MeOH 9:1): Rf=0.26.

Sources & evidence

ORD record
ord-72e94d3cef564021a90feda4b34feef6
Source dataset
uspto-grants-2012_03
Patent number
US08133886B2

Reaction notes

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