Methylamine → HCID 23652720, compound

Participants

Reaction Steps

A solution of 40 mg (0.087 mMol) 6-(6-chloro-pyrimidin-4-ylmethyl)-naphthalene-1-carboxylic acid (4-fluoro-3-trifluoromethyl-phenyl)-amide and 750 μl methylamine (2 M in THF; 1.5 mMol) in 1.5 ml THF is stirred in a sealed vessel for 20 h at rt and 3.5 h at 65° C. Concentration and chromatography (Combi Flash; EtOAc→EtOAc/EtOH 9:1) gives the title compound: MS: [M+1]+=455; TLC(EtOAc/EtOH 9:1): Rf=0.27.

Provenance & Evidence