反应详情

温度

62 °C

A suspension of 6.56 g (40 mMol) 2-amino-4,6-dichloropyrimidine and 7.52 g (40 mMol) 6-hydroxy-1-naphthoic acid in 160 ml acetone and 80 ml 1 N aqueous NaOH is heated to 62° C. for 36 h. The mixture is cooled to rt, partially concentrated in vacuo and the residue poured into 1.6 l icewater. Under vigorous stirring, 20 ml 2 N HCl are added dropwise (pH≈4). After stirring the suspension for 30 min, the title compound is filtered off and washed with water; HPLC: tRet=12.8.

1. temperatureThe mixture is cooled to rt
2. concentrationpartially concentrated in vacuo
3. additionthe residue poured into 1.6 l icewater
4. additionUnder vigorous stirring, 20 ml 2 N HCl are added dropwise (pH≈4)
5. filtrationthe title compound is filtered off
6. washwashed with water