HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(2-Amino-6-chloro-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid → 6-(2-Amino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(2-Amino-6-chloro-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid | HCID 86625276 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 6-(2-Amino-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid | HCID 57455159 | — |
Reaction Steps
24.4 g (77.5 mMol) 6-(2-amino-6-chloro-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid in 3.5 l THF and 100 ml Et3N are hydrogenated in the presence of 15 g Pd/C (10%; Engelhard 4505). The catalyst is filtered off and washed extensively with THF. Partial concentration of the filtrate precipitates the title compound: MS: [M+1]+=282.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08133886B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-68c715efa3d64ca591aa818f4019aad2 |
| Source note | uspto-grants-2012_03 |