Sodium borohydride → HCID 23653201, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 523 mg (1.048 mMol) 4-[5-(4-fluoro-3-trifluoromethyl-phenylcarbamoyl)-naphthalen-2-yloxy]-pyrimidine-2-carboxylic acid ethyl ester in 13.8 ml tert-butanol, 119 mg (3.14 mMol) NaBH4 are added. This mixture is stirred for 2 h at 70° C. and then concentrated in vacuo. The residue is diluted with water and EtOAc, the aq. phase separated off and extracted twice with EtOAc. The organic layers are washed with brine, dried (Na2SO4) and concentrated. Chromatography [Combi Flash; CH2Cl2/(CH2Cl2/tertBuOH 1:1) 99:1→83:17] and trituration from DIPE gives the title compound: Anal. (+0.3H2O+0.4 DIPE): C, H, N, F; MS: [M+1]+=458; TLC (CH2Cl2/acetone 9:1): Rf=0.44.

Provenance & Evidence