Triethyl phosphite → HCID 86640229, compound

HRID 1094529Notes

Reaction equation

HRID 1094529 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:15])[C:11]([F:14])([F:13])[F:12])=[CH:5][C:4]=1[C:16]([F:19])([F:18])[F:17].[CH2:20]([O:22][P:23]([O:27]CC)[O:24][CH2:25][CH3:26])[CH3:21]>C1(C)C=CC=CC=1>[CH2:20]([O:22][P:23]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:15])[C:11]([F:14])([F:13])[F:12])=[CH:5][C:4]=1[C:16]([F:19])([F:18])[F:17])(=[O:27])[O:24][CH2:25][CH3:26])[CH3:21]

Participants

4

Reactant 2

HCID 31215Triethyl phosphiteHCID 57351764N-[4-(Bromomethyl)-3-(trifluoromethyl)phenyl]-2,2,2-trifluoroacetamide

Product 1

HCID 86640229HCID 86640229, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 1.75 g (5 mMol) N-(4-bromomethyl-3-trifluoromethyl-phenyl)-2,2,2-trifluoro-acetamide (WO 2005/051366; Step 14.2) and 1.05 ml (6 mMol) triethylphosphite in 10 ml toluene is heated at 120° C. for 6 h. After cooling, the suspension is filtered and the crystalline solid washed with hexane to give the title compound as a colourless solid.

Workup

  1. temperatureAfter cooling
  2. filtrationthe suspension is filtered
  3. washthe crystalline solid washed with hexane

Sources & evidence

ORD record
ord-b26500a62b20480e82a7a022bde54a80
Source dataset
uspto-grants-2012_03
Patent number
US08133886B2

Reaction notes

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