Hydrochloric Acid → HCID 23652997, compound

Participants

Reaction Steps

A solution of 2.3 ml hydrogen chloride (4 M in dioxane) is added to a stirred solution of 0.24 g (0.38 mmol) [(3S)-1-[4-[[[6-(6-acetylamino-pyrimidin-4-yloxy)-naphthalen-1-yl]carbonyl-]-amino]-2-(trifluoromethyl)phenyl]-3-piperidinyl]-carbamic acid, 1,1-dimethylethyl ester (Ex. 35) in 2.3 ml dioxan at room temperature. After 90 min, the mixture is poured into an excess of saturated aqueous NaHCO3. The crude product is filtered and purified by chromatography (SiO2, CH2Cl2/EtOH/NH3 90:9:1) to afford the title compound as a beige solid: m.p.: 218-228° C.

Provenance & Evidence