4-Fluorobenzoyl chloride → HCID 57559156, compound

HRID 1094560Notes

Reaction equation

HRID 1094560 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]2[NH:8][C:7]3[C:12]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][NH:14][CH2:15][CH2:16][C:6]=3[C:5]=2[CH:4]=1.[F:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](Cl)=[O:28])=[CH:25][CH:24]=1>>[F:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([N:14]2[CH2:15][CH2:16][C:6]3[C:5]4[CH:4]=[C:3]([O:2][CH3:1])[CH:11]=[CH:10][C:9]=4[NH:8][C:7]=3[C:12]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13]2)=[O:28])=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 66640172HCID 66640172, compound

Product 1

HCID 57559156HCID 57559156, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2A by using ethyl 9-methoxy-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate and 4-fluorobenzoyl chloride; 1H-NMR (CDCl3): δ 10.42 (1H, br s), 7.98 (1H, s), 7.62 (2H, m), 7.28 (1H, m), 7.16 (2H, m), 6.93 (1H, d), 6.88 (1H, dd), 4.24 (4H, m), 3.88 (3H, s), 3.23 (2H, m), 1.23 (3H, t); MS (ES): 409 (MH+).

Sources & evidence

ORD record
ord-a22b06b2e4b5424d9034538607eb32cb
Source dataset
uspto-grants-2012_03
Patent number
US08133992B2

Reaction notes

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