4-Fluorobenzoyl chloride → HCID 57559155, compound

HRID 1094569Notes

Reaction equation

HRID 1094569 reaction equation
[CH3:1][CH:2]1[NH:15][CH:14]=[C:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:5]2[NH:6][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:4]=2[CH2:3]1.[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][CH:23]=1>>[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26]([N:15]2[CH:2]([CH3:1])[CH2:3][C:4]3[C:12]4[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=4[NH:6][C:5]=3[C:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:14]2)=[O:27])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 66640196Ethyl 2-methyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate

Product 1

HCID 57559155HCID 57559155, compound

Procedure

The title compound was prepared in a manner similar to that described in Example 2A by using ethyl 2-methyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate and 4-fluorobenzoyl chloride; 1H-NMR (CDCl3): δ 10.44 (1H, br s), 8.01 (1H, s), 7.63 (2H, m), 7.52 (1H, d), 7.39 (1H, d), 7.24 (4H, m), 5.61 (1H, br s), 4.22 (2H, m), 3.43 (1H, dd), 3.10 (1H, dd), 1.19 (3H, t), 1.06 (3H, d); MS (ES): 393 (MH+).

Sources & evidence

ORD record
ord-7cd5df0965ea414f85bae50ff6dc40d4
Source dataset
uspto-grants-2012_03
Patent number
US08133992B2

Reaction notes

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