Hydrochloric Acid → HCID 66637317, compound

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A mixture of 2-methyl-N-[1-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)ethyl]propane-2-sulfinamide (430 mg, 1.53 mmol) and 10% hydrochloride in MeOH (10 ml) was stirred at room temperature for 4 hours. The mixture was concentrated, triturated with MeOH to give 265 mg (81%) of the title compound as a pale brown solid. 1H NMR (300 MHz, DMSO-d6) δ ppm 1.50 (3H, d, J=6.6 Hz), 4.40-4.31 (1H, m), 6.94 (1H, d, J=7.3 Hz), 7.06 (1H, d, J=8.1 Hz), 7.10 (1H, s), 8.38 (2H, br.s), 10.74 (1H, br.s), 10.83 (1H, bs). MS (ESI) m/z 178 (M+H)+, 176 (M−H)−.

Provenance & Evidence