Hydrochloric Acid → HCID 59544167, compound

Participants

Reaction Conditions

Reaction Steps

To a methanol (15 ml) and 2N sodium hydroxide aqueous solution (5 ml), methyl 6-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)-2-naphthoate (3.45 mmol, 1.0 g) was added and the mixture was stirred for 2 hours at 60° C. Then, the reaction mixture was acidified with 2M hydrogen chloride aqueous solution and partitioned with ethyl acetate (50 ml). The organic layer was dried over sodium sulfate and evaporated to give the title compound as a white solid (0.9 g, quant). 1H NMR (300 MHz, CDCl3) δ ppm 1.81 (3H, s), 6.85 (1H, s), 7.70-8.75 (6H, m), 12.94 (1H, br.s).

Provenance & Evidence