反应详情

温度

80 °C

A mixture of 4-oxo-3,4-dihydroquinazoline-7-carboxylic acid (2.5 g, 13.15 mmol) in 80 mL of methanol was added thionyl chloride (2.5 mL) at 5° C. and then refluxed at 80° C. over night. The reaction mixture was concentrated under vacuum and the residue dissolved in ethyl acetate. The organic layer was washed with 10% aqueous NaHCO3, water, brine and dried. The solvent was removed to give methyl 4-oxo-3,4-dihydroquinazoline7-carboxylate in 70% yield as solid.

1. concentrationThe reaction mixture was concentrated under vacuum
2. dissolutionthe residue dissolved in ethyl acetate
3. washThe organic layer was washed with 10% aqueous NaHCO3, water, brine
4. customdried
5. customThe solvent was removed