HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzylamine → HCID 66637595, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzylamine | HCID 66036 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 131729499 | HCID 131729499 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 66637595 | HCID 66637595 | 65% |
Reaction Steps
3-(2-flourobenzyl)-4-oxo-3,4-dihydroquinazoline-7-carboylate (65 mg, 0.218 mmol was dissolved in DCM (10 mL) followed by the addition of DIEA (0.1 mL), HATU (100 mg) and 4-chlorobenzylamine (34 mg, 0.239 mmol). The mixture was stirred at RT overnight. The residue was semi-purified by flash chromatography and then further purified by rotary prep TLC using DCM-Ether (1:1) to give the desired product in 65% yield with HPLC purity of ≧95%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08133998B2 |
| Source dataset | uspto-grants-2012_03 |
| ORD ID | ord-dc4b2dc3012944c185edd26659a85f2f |
| Source note | uspto-grants-2012_03 |