反应详情

To a Stirred solution of 1-(2-hydroxyethyl)pyrrolidin-2-one (2.6 g, 20 mmol) in pyridine (15 ml) was added methanesulfonyl chloride (2.28 g, 20 mmol) and the reaction mixture was stirred at RT overnight. Solution was concentrated and diluted with ethyl acetate (50 ml) and washed with water (50 ml). Ethyl acetate layer was separated, dried over anhydrous sodium sulfate and evaporated to yield 3.0 g of 2-(2-oxopyrrolidin-1-yl)ethyl methanesulfonate, as an oil (yield: 75%).

1. concentrationSolution was concentrated
2. additiondiluted with ethyl acetate (50 ml)
3. washwashed with water (50 ml)
4. customEthyl acetate layer was separated
5. dry with materialdried over anhydrous sodium sulfate
6. customevaporated