反应详情

Certain operational steps are well known in the art and, unless otherwise indicated, any known method for performing these functions may be used in the processes of this invention. For example, solvents may be removed by distillation in atmosphere or under vacuum. Drying may be accomplished by evaporation, spray drying, drying under vacuum, and freeze-drying. Stirring means any method for blending or mixing a reaction mixture. Reagents and/or reaction mixtures may be combined by adding one to the other, for example, water may be poured into a reaction mixture. In general the methods of this invention involve various such steps, e.g. combining esomeprazole base with a suitable counterion such as magnesium, to form esomeprazole magnesium, hydrating the esomeprazole magnesium by combining with water to form an esomeprazole magnesium hydrate, removing organic impurities and excess magnesium, and drying the esomeprazole magnesium hydrate (preferably trihydrate) to obtain a hydrate of esomeprazole magnesium in the form of an amorphous solid.