Acetic Anhydride → HCID 13345321, compound

HRID 1094769Notes

Reaction equation

[CH3:1][C:2]1[N:7]=[C:6]([C:8]([OH:10])=O)[C:5]([C:11]([OH:13])=[O:12])=[CH:4][CH:3]=1.C(OC(=O)C)(=O)C>>[CH3:1][C:2]1[N:7]=[C:6]2[C:8](=[O:10])[O:13][C:11](=[O:12])[C:5]2=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 5425676-Methyl-2,3-pyridinedicarboxylic acid

Product 1

HCID 13345321HCID 13345321, compound

Conditions

Temperature: 100 °C

Procedure

In a 100 ml round-bottomed flask 6-methyl-2,3-pyridinedicarboxylic acid (10 g, 55.2 mmol) and acetic anhydride (26 ml, 276 mmol) were added and heated at 100° C. under nitrogen for 5 hours. After this time the volatiles were removed under vacuum to give the title compound D32 (8.2 g) as a slightly brown solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.41 (d, 1 H), 7.82 (d, 1 H), 2.73 (s, 3 H).

Workup

customAfter this time the volatiles were removed under vacuum

Sources & evidence

ORD record: ord-35cd43482bc54903b6c91a9f05b1dd00
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08133908B2

Reaction notes

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