Hydrochloric Acid → HCID 66636934, compound

Participants

Reaction Steps

To a solution of N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3-azabicyclo[4.1.0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine (0.036 g) in DCM (1 ml) was added HCl (1 M in Et2O) (0.161 ml, 0.161 mmol) and stirred for 30 minutes. The solvents were removed under reduced pressure to give a yellowish solid, which was triturated with Et2O (3×1 ml). The solvent was removed by suction and the residue was dried under vacuum at 40° C. overnight to yield the title compound E1 (0.038 g) as white solid. HPLC (walk-up): rt=4.48 min MS: (ES/+) m/z: 449 (M+1−HCl). C23H27F3N4O2HCl requires 484. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.29-8.45 (m, 1 H), 7.77-7.89 (m, 1 H), 7.58-7.66 (m, 2 H), 7.33-7.42 (m, 1 H), 6.85-7.04 (m, 1 H), 4.13-4.21 (m, 1 H), 3.95-4.02 (m, 2 H), 3.37-3.70 (m, 3 H), 2.60-2.74 (m, 1 H), 2.38-2.48 (m, 4 H), 1.56-1.73 (m, 2 H), 1.02-1.32 (m, 2 H), 0.82-0.96 (m, 4 H), 0.64-0.73 (m, 1 H), 0.20-0.28 (m, 1 H).

Provenance & Evidence