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Diethyl squarate → Methyl (2S)-3-{3'-[(2-ethoxy-3,4-dioxo-1-cyclobuten-1-yl) amino][1,1'-biphenyl]-4-yl}-2-mesitylsulfonylamino-propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl squarate | HCID 123228 | — |
| 反応物 | HCID 11430900 | HCID 11430900 | — |
| 溶媒 | 1-Propanol | HCID 1031 | — |
| 生成物 | Methyl (2S)-3-{3'-[(2-ethoxy-3,4-dioxo-1-cyclobuten-1-yl) amino][1,1'-biphenyl]-4-yl}-2-mesitylsulfonylamino-propanoate | HCID 56989219 | 59% |
反応手順
2 g of Methyl (2S)-3-(3′-amino[1,1′-biphenyl]-4-yl)-2-mesitylsulfonylamino-propanoate 12.1.2 were mixed with 0.75 g 3,4-diethoxy-3-cyclobuten-1,2-dion in 40 ml 1 propanol and refluxed for 20 h. Purification by flash chromatography (dichloromethane/acetic acid ethyl ester 10+1) yielded 1,5 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094911B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-eeba8983ef704b9db8cf16948c3268c1 |
| 出典メモ | uspto-grants-2006_08 |